זעפרן Crocus sativus

מקורות מחקריים:

1. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression.

Mazidi M, et al.

J Complement Integr Med. 2016 Jun 1;13(2):195-9. doi: 10.1515/jcim-2015-0043.

2. Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014 Nov;29(6):517-27

3. Asadollahi M, et al. Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial. J Ethnopharmacol. 2019 Jun 28;238:111833.

4. Tóth B, et al. The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis. Planta Med. 2019 Jan;85(1):24-31. 

5. Asbaghi O, Soltani S, Norouzi N, Milajerdi A, Choobkar S, Asemi Z. The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019;47:102158.

6. Tahvilian N, Masoodi M, Faghihi Kashani A, et al. Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double-blind, placebo-controlled study [published online ahead of print, 2020 Oct 4]. Phytother Res. 2020;10.1002/ptr.6848.

7. Broadhead GK, et al. Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial. Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):31-40.

Shakiba M, et al. Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial. Avicenna J Phytomed. 2018 Nov-Dec;8(6):513-523.

8. Hamidi Z, Aryaeian N, Abolghasemi J, et al. The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial [published online ahead of print, 2020 Feb 11]. Phytother Res. 2020;10.1002/ptr.6633.

9. Ghaderi A, Asbaghi O, Reiner Ž, et al. The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complement Ther Med. 2020;48:102250.

10. Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics: A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Trial.

Mohammadzadeh-Moghadam H, et al.

J Evid Based Complementary Altern Med. 2015 Oct;20(4):283-6. doi: 10.1177/2156587215583756. Epub 2015 May 6.

11. Jackson PA, Forster J, Khan J, Pouchieu C, Dubreuil S, Gaudout D, Moras B, Pourtau L, Joffre F, Vaysse C, Bertrand K, Abrous H, Vauzour D, Brossaud J, Corcuff JB, Capuron L, Kennedy DO. Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Front Nutr. 2021 Feb 1;7:606124.

12. Rahmani J, Bazmi E, Clark C, Hashemi Nazari SS. The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2020;49:102298.

13. Rahmani J, et al. The effect of saffron on weight and lipid profile: A systematic review, meta-analysis, and dose-response of randomized clinical trials. Phytother Res. 2019 Sep;33(9):2244-2255.