אנדרוגרפיס – Andrographis paniculata

מחקר שבדק את היתרונות של אנדרוגרפיס בטיפול בפריקת הגרון והאמידה בגורמים אלרגיים של מחלות הגרון והטונזילות. נמצא כי אנדרוגרפיס יכולה להקל על תסמיני הגרון הכרוניים ולהפחית את הדלקות הטונזילות.

Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai. 1991 Mar;74(3):127-31.

• מחקר זה בדק את ההשפעה של אנדרוגרפיס על פעילות החמצון של הכבד. נמצא כי תמצית אנדרוגרפיס עשויה לשפר את פעילות החמצון הנוגדת בכבד.

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Hancke JL, Srivastav S, Cáceres DD, Burgos RA. A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytother Res. 2019 May;33(5):1469–79. https://www.ncbi.nlm.nih.gov/pubmed/30968986

Suriyo T, Pholphana N, Ungtrakul T, et al. Clinical Parameters following Multiple Oral Dose Administration of a Standardized Andrographis paniculata Capsule in Healthy Thai Subjects. Planta Med. 2017 Jun;83(9):778–89. https://www.ncbi.nlm.nih.gov/pubmed/28249303

Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016 May 23;16:77. https://www.ncbi.nlm.nih.gov/pubmed/27215274

Phunikhom K, Khampitak K, Aromdee C et al. Effect of Andrographis paniculata Extract on Triglyceride Levels of the Patients with Hypertriglyceridemia: A Randomized Controlled Trial. J Med Assoc Thai. 2015 Jul;98 Suppl 6:S41-47. https://www.ncbi.nlm.nih.gov/pubmed/26434249

Sandborn WJ, Targan SR, Byers VS, et al. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013 Jan;108(1):90–8. https://www.ncbi.nlm.nih.gov/pubmed/23044768

Saxena RC, Singh R, Kumar P, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010 Mar;17(3–4):178–85. https://www.ncbi.nlm.nih.gov/pubmed/20092985

Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res. 2000; 14(5):333–338. https://www.ncbi.nlm.nih.gov/pubmed/10925397

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Sithisomwongsִe N, Pengchata J, Cheewapatana S, et al. Acute and chronic toxicity of Andrographis paniculata Nee. Thai J Pharm Sci. 1989; 14(2):109–117.

Dutta A, Sukul NC. Filaricidal properties of a wild herb, Andrographis paniculata. J Helminthol. 1982; 56(2):81–84. https://www.ncbi.nlm.nih.gov/pubmed/7201486

Balap A, Lohidasan S, Sinnathambi A, Mahadik K. Herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide on pharmacokinetic and pharmacodynamic of naproxen in rats. J Ethnopharmacol. 2017 Jan 4;195:214–21. https://www.ncbi.nlm.nih.gov/pubmed/27847337

Balap A, Lohidasan S, Sinnathambi A, Mahadik K. Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats. Phytother Res. 2017 Jan;31(1):75–80. https://www.ncbi.nlm.nih.gov/pubmed/27714886

Chien CF, Wu YT, Lee WC, et al. Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact. 2010; 184:458–465. https://www.ncbi.nlm.nih.gov/pubmed/20096675

Tan ML, Lim LE. The effects of Andrographis paniculata (Burm.f.) Nees extract and diterpenoids on the CYP450 isoforms' activities, a review of possible herb-drug interaction risks. Drug Chem Toxicol. 2015;38(3):241-53. https://www.ncbi.nlm.nih.gov/pubmed/25156015

Pekthong D, Blanchard N, Abadie C, et al. (2009). Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chem Biol Interact 179:247–255. https://www.ncbi.nlm.nih.gov/pubmed/19041297

Zhang X, Zhang X, Wang X, Zhao M. Influence of andrographolide on the pharmacokinetics of warfarin in rats. Pharm Biol. 2018 Dec;56(1):351–6. https://www.ncbi.nlm.nih.gov/pubmed/29983086

Pekthong D, Martin H, Abadie C, et al. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J Ethnopharmacol. 2008; 115: 432–440. https://www.ncbi.nlm.nih.gov/pubmed/18053665

Chatuphonprasert W, Remsungnen T, Nemoto N, Jarukamjorn K. Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. Toxicol In Vitro. 2011 Dec;25(8):1757-63. https://www.ncbi.nlm.nih.gov/pubmed/21963808

Ooi JP, Kuroyanagi M, Sulaiman SF, Muhammad TS, Tan ML. Andrographolide and 14-deoxy-11,12-didehydroandrographolide inhibit cytochrome P450s in HepG2 hepatoma cells. Life Sci. 2011 Feb 28;88(9-10):447-54. https://www.ncbi.nlm.nih.gov/pubmed/21219911

Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE. In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). J Ethnopharmacol. 2011; 133:881–887. https://www.ncbi.nlm.nih.gov/pubmed/21093571

Hanapi N, Azizi J, Ismail S, Mansor S. (2010). Evaluaition of selected Malaysian medicinal plants on phase I drug metabolzing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro. Int J Pharmacol 6: 494–499. http://docsdrive.com/pdfs/ansinet/ijp/2010/494-499.pdf

Pan Y, Abd-Rashid BA, Ismail Z, et al. (2011a). In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. J Nat Med 65: 440–447. https://www.ncbi.nlm.nih.gov/pubmed/21365364

Jarukamjorn K, Don-in K, Makejaruskul C, et al. (2006). Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes. J Ethnopharmacol 105:464–467. https://www.ncbi.nlm.nih.gov/pubmed/16406417

Uchaipichat V. In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans. Drug Metab Pharmacokinet. 2018 Feb;33(1):67–76. https://www.ncbi.nlm.nih.gov/pubmed/29241692

Chong YM, Kaur G, Tan ML. Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor. J Asian Nat Prod Res. 2019 Aug;21(8):754–71. https://www.ncbi.nlm.nih.gov/pubmed/30606060

Rehman SU, Choi MS, Choe K, Yoo HH. Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management. Arch Pharm Res. 2015 Jul;38(7):1281-98. https://www.ncbi.nlm.nih.gov/pubmed/25475096

Reyes, B., N. Bautista, N. Tanquilut, R. et al., 2006. Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. Journal of Ethnopharmacology 105: 196–200. https://www.ncbi.nlm.nih.gov/pubmed/16298503

Borhanuddin, M., M. Shamsuzzoha, and A.H. Hussain. 1994. Hypoglycemia effects of Andrographis paniculata Nees on non-diabetic rabbits. Bangladesh Medical Research Council Bulletin 20: 2–24. https://www.ncbi.nlm.nih.gov/pubmed/7880153

Zhang, X.F., and B.K. Tan. 2000. Antihyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats. Clinical and Experimental Pharmacology and Physiology 27: 358–363. https://www.ncbi.nlm.nih.gov/pubmed/10831236

Yu, B.C., W.C. Chen, and J.T. Cheng. 2003a. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Medica 69: 1075–1079. https://www.ncbi.nlm.nih.gov/pubmed/14750020

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Thisoda P, Rangkadilok N, Pholphana N, et al. Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. Eur J Pharmacol 2006; 553(1-3):39-45. https://www.ncbi.nlm.nih.gov/pubmed/17081514

Burgos RA, Hidalgo MA, Monsalve J, et al. 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. Planta Med 2005;71(7):604-608. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2005-871264

Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine 2006;13(5):318-323. https://www.ncbi.nlm.nih.gov/pubmed/16635739

Panossian A, Davtyan T, Gukassyan N, et al. Effect of andrographolide and kan jang – fixed combination of extract SHA-10 and extract SHE-3 – on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture. Phytomed. 2002; 9:598-605. https://www.ncbi.nlm.nih.gov/pubmed/12487323

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Li L, et al. The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment - from preclinical perspectives. Sci Rep. 2017 Apr 12;7(1):854. https://www.ncbi.nlm.nih.gov/pubmed/28405006

Panossian A, Kochikian A, Gabrielian E, et al. Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats. Phytomedicine. 1999; 6(3):157–161. https://www.ncbi.nlm.nih.gov/pubmed/10439479

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Akbarsha MA, Manivannan B, Hamid KS, Vijayan B. Antifertility effect of Andrographis paniculata (Nees) in male albino rats. Indian J Exp Biol. 1990; 28(5):421-426. https://www.ncbi.nlm.nih.gov/pubmed/2401516

Akbarsha MA, Manivannan B. Biochemical changes in the testis and accessory organs of albino rats on treatment with Andrographis paniculata Nees. Indian J Comp Anim Physiol. 1993; 11:103- 108. https://ci.nii.ac.jp/naid/10021823990/

Akbarsha M, Murugaian P. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: Effect on the testis and the cauda epididymidal spermatozoa. Phytotherapy Research. 2000; 14: 432-435. https://www.ncbi.nlm.nih.gov/pubmed/10960897

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