קמומיל רומי – Chamaemelum nobile

Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998. http://annals.org/aim/article-abstract/712613.

Rowe AH. Camomile (Anthemis cotula) as a skin irritant. J. Allergy, 5:383-8, 1934. https://www.jacionline.org/article/S0021-8707(34)90162-3/fulltext.

McGeorge BC, Steele MC. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Cont. Derm., 24:139-140, 1991. https://www.ncbi.nlm.nih.gov/pubmed/2040155

Pereira F, Santos R, Pereira A. Contact dermatitis from chamomile tea. Cont Derm, 36:307, 1997. https://www.ncbi.nlm.nih.gov/pubmed/9237012

Hieu TH, Dibas M, Surya Dila KA, et al. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother Res. 2019 Jun;33(6):1604-1615. https://www.ncbi.nlm.nih.gov/pubmed/31006899

Habersang S, Leuschner F, Isaac O, Thiemer K. [Pharmacological studies with compounds of chamomile. IV. Studies on toxicity of (-)-alpha-bisabolol (author's transl)]. Planta Med 1979;37(2):115-123. https://www.ncbi.nlm.nih.gov/pubmed/117474

Konig GM, Wright AD, Keller WJ, et al. Hypoglycaemic activity of an HMG-containing flavonoid glucoside, chamaemeloside, from Chamaemelum nobile. Planta Med 1998;64(7):612-614. https://www.ncbi.nlm.nih.gov/pubmed/9810266

Ikram, M. Medicinal plants as hypocholesterolemic agents. J Pak.Med Assoc 1980;30(12):278-281. https://europepmc.org/abstract/med/6782266

Levy I, Attias S, Ben‐Arye E, Goldstein L, Schiff E. Adverse events associated with interactions with dietary and herbal supplements among inpatients. Br J Clin Pharmacol 2017; 83: 836–845. https://www.ncbi.nlm.nih.gov/pubmed/27759172

Goldstein LH, Elias M, Ron‐Avraham G, Biniaurishvili BZ, Mad‐jar M, Kamargash I, et al. Consumption of herbal remedies and dietary supplements amongst patients hospitalized in medical wards. Br J Clin Pharmacol 2007; 64: 373–380. https://www.ncbi.nlm.nih.gov/pubmed/17425631

Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010. https://www.eclecticherb.com/herb-contraindications-drug-interactions

Farnsworth NR, Bingel AS, Cordell GA, et al. Potential value of plants as sources of new antifertility agents I. J. Pharm. Sci., 64:535-598, 1975. https://www.ncbi.nlm.nih.gov/pubmed/167146

McGuffin M, Hobbs C, Upton R, Goldberg A (ed.). Botanical Safety Handbook. CRC Press, Boca Raton, 1997. https://www.crcpress.com/American-Herbal-Products-Associations-Botanical-Safety-Handbook/Gardner-McGuffin/p/book/9781466516946.

Moerman DE. Native American Ethnobotany, Timber Press, Portland, Ore., 1999. https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.2600640404

Cuzzolin L, Francini-Pesenti F, Verlato G, et al. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiol. Drug Safety, 19:1151-1158, 2010. https://www.ncbi.nlm.nih.gov/pubmed/20872924

Colombo D, Lunardon L, Bellia G. Cyclosporine and herbal supplement interactions. J Toxicol. 2014;2014:145325. Epub 2014 Jan 12. https://pubmed.ncbi.nlm.nih.gov/24527031/

European Medicines Agency. Assessment report on Matricaria recutita L., flos and Matricaria recutita L., aetheroleum, Final. https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-matricaria-recutita-l-flos-matricaria-recutita-l-aetheroleum-first-version_en.pdf

Nowack R, Nowak B. Herbal teas interfere with cyclosporin levels in renal transplant patients. Nephrol Dial Transplant. 2005 Nov;20(11):2554-6. https://pubmed.ncbi.nlm.nih.gov/16046518/

Eddouks M, Lemhadri A, Zeggwagh NA, Michel JB. Potent hypoglycaemic activity of the aqueous extract of Chamaemelum nobile in normal and streptozotocin-induced diabetic rats. Diabetes Res Clin Pract. 2005 Mar;67(3):189-95. https://pubmed.ncbi.nlm.nih.gov/15713350/

Hashikawa-Hobara N, Otsuka A, Ishikawa R, Hashikawa N. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomed Pharmacother. 2019 Oct;118:109263. https://pubmed.ncbi.nlm.nih.gov/31369988/

Zeggwagh NA, Moufid A, Michel JB, Eddouks M. Hypotensive effect of Chamaemelum nobile aqueous extract in spontaneously hypertensive rats. Clin Exp Hypertens. 2009 Jul;31(5):440-50. https://pubmed.ncbi.nlm.nih.gov/19811353/

Zeggwagh NA, Michel JB, Eddouks M. Vascular effects of aqueous extract of Chamaemelum nobile: in vitro pharmacological studies in rats. Clin Exp Hypertens. 2013;35(3):200-6. https://pubmed.ncbi.nlm.nih.gov/22866985/

Melegari M, Albasini A, Pecorari P, et al. Chemical characteristics and pharmacological properties of the essential oils of Anthemis nobilis. Fitoterapia 1988, 59:449-455. https://eurekamag.com/research/007/106/007106160.php

European Medicines Agency. Assessment report on Chamaemelum nobile (L.) All., flos. https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-chamaemelum-nobile-l-all-flos_en.pdf

Al-Snafi AE. Medical importance of Anthemis nobile (Chamaemelum nobile)- a review. Asian Journal of Pharmaceutical Science & Technology, 2016, Vol 6, Issue 2, 89-95. https://www.researchgate.net/publication/313742660

Tognolini M, Barocelli E, Ballabeni V, et al. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci, 78(13), 2006, 1419-1432. https://pubmed.ncbi.nlm.nih.gov/16274702/